The impact of parkinson's disease on the cortical mechanisms that support auditory-motor integration for voice control.
Identifieur interne : 000169 ( Main/Exploration ); précédent : 000168; suivant : 000170The impact of parkinson's disease on the cortical mechanisms that support auditory-motor integration for voice control.
Auteurs : Xiyan Huang [République populaire de Chine] ; Xi Chen [République populaire de Chine] ; Nan Yan [République populaire de Chine] ; Jeffery A. Jones [Canada] ; Emily Q. Wang ; Ling Chen [République populaire de Chine] ; Zhiqiang Guo ; Weifeng Li [République populaire de Chine] ; Peng Liu [République populaire de Chine] ; Hanjun Liu [République populaire de Chine]Source :
- Human brain mapping [ 1097-0193 ] ; 2016.
Abstract
Several studies have shown sensorimotor deficits in speech processing in individuals with idiopathic Parkinson's disease (PD). The underlying neural mechanisms, however, remain poorly understood. In the present event-related potential (ERP) study, 18 individuals with PD and 18 healthy controls were exposed to frequency-altered feedback (FAF) while producing a sustained vowel and listening to the playback of their own voice. Behavioral results revealed that individuals with PD produced significantly larger vocal compensation for pitch feedback errors than healthy controls, and exhibited a significant positive correlation between the magnitude of their vocal responses and the variability of their unaltered vocal pitch. At the cortical level, larger P2 responses were observed for individuals with PD compared with healthy controls during active vocalization due to left-lateralized enhanced activity in the superior and inferior frontal gyrus, premotor cortex, inferior parietal lobule, and superior temporal gyrus. These two groups did not differ, however, when they passively listened to the playback of their own voice. Individuals with PD also exhibited larger P2 responses during active vocalization when compared with passive listening due to enhanced activity in the inferior frontal gyrus, precental gyrus, postcentral gyrus, and middle temporal gyrus. This enhancement effect, however, was not observed for healthy controls. These findings provide neural evidence for the abnormal auditory-vocal integration for voice control in individuals with PD, which may be caused by their deficits in the detection and correction of errors in voice auditory feedback. Hum Brain Mapp 37:4248-4261, 2016. © 2016 Wiley Periodicals, Inc.
DOI: 10.1002/hbm.23306
PubMed: 27400999
Affiliations:
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auditory-motor integration for voice control.</title><author><name sortKey="Huang, Xiyan" sort="Huang, Xiyan" uniqKey="Huang X" first="Xiyan" last="Huang">Xiyan Huang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rehabilitation Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rehabilitation Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080</wicri:regionArea><wicri:noRegion>510080</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Xi" sort="Chen, Xi" uniqKey="Chen X" first="Xi" last="Chen">Xi Chen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rehabilitation Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rehabilitation Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080</wicri:regionArea><wicri:noRegion>510080</wicri:noRegion></affiliation></author><author><name sortKey="Yan, Nan" sort="Yan, Nan" uniqKey="Yan N" first="Nan" last="Yan">Nan Yan</name><affiliation wicri:level="3"><nlm:affiliation>CAS Key Laboratory of Human-Machine Intelligence-Synergy Systems, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>CAS Key Laboratory of Human-Machine Intelligence-Synergy Systems, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen</wicri:regionArea><placeName><settlement type="city">Shenzhen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Jones, Jeffery A" sort="Jones, Jeffery A" 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Wang</name><affiliation><nlm:affiliation>Department of Communication Disorders and Sciences, RUSH University Medical Center, 1653 West Congress Parkway, 203 SENN, Chicago, Illinois, 60612.</nlm:affiliation><wicri:noCountry code="subField">60612</wicri:noCountry></affiliation></author><author><name sortKey="Chen, Ling" sort="Chen, Ling" uniqKey="Chen L" first="Ling" last="Chen">Ling Chen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Neurology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080</wicri:regionArea><wicri:noRegion>510080</wicri:noRegion></affiliation></author><author><name sortKey="Guo, Zhiqiang" sort="Guo, Zhiqiang" uniqKey="Guo Z" first="Zhiqiang" last="Guo">Zhiqiang Guo</name><affiliation><nlm:affiliation>Department of Biomedical Engineering School of Engineering, Sun Yat-Sen University, Guangzhou, China, 510006.</nlm:affiliation><wicri:noCountry code="subField">510006</wicri:noCountry></affiliation></author><author><name sortKey="Li, Weifeng" sort="Li, Weifeng" uniqKey="Li W" first="Weifeng" last="Li">Weifeng Li</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rehabilitation Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rehabilitation Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080</wicri:regionArea><wicri:noRegion>510080</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Peng" sort="Liu, Peng" uniqKey="Liu P" first="Peng" last="Liu">Peng Liu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rehabilitation Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rehabilitation Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080</wicri:regionArea><wicri:noRegion>510080</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Hanjun" sort="Liu, Hanjun" uniqKey="Liu H" first="Hanjun" last="Liu">Hanjun Liu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rehabilitation Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Rehabilitation Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080</wicri:regionArea><wicri:noRegion>510080</wicri:noRegion></affiliation></author></analytic><series><title level="j">Human brain mapping</title><idno type="eISSN">1097-0193</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Several studies have shown sensorimotor deficits in speech processing in individuals with idiopathic Parkinson's disease (PD). The underlying neural mechanisms, however, remain poorly understood. In the present event-related potential (ERP) study, 18 individuals with PD and 18 healthy controls were exposed to frequency-altered feedback (FAF) while producing a sustained vowel and listening to the playback of their own voice. Behavioral results revealed that individuals with PD produced significantly larger vocal compensation for pitch feedback errors than healthy controls, and exhibited a significant positive correlation between the magnitude of their vocal responses and the variability of their unaltered vocal pitch. At the cortical level, larger P2 responses were observed for individuals with PD compared with healthy controls during active vocalization due to left-lateralized enhanced activity in the superior and inferior frontal gyrus, premotor cortex, inferior parietal lobule, and superior temporal gyrus. These two groups did not differ, however, when they passively listened to the playback of their own voice. Individuals with PD also exhibited larger P2 responses during active vocalization when compared with passive listening due to enhanced activity in the inferior frontal gyrus, precental gyrus, postcentral gyrus, and middle temporal gyrus. This enhancement effect, however, was not observed for healthy controls. These findings provide neural evidence for the abnormal auditory-vocal integration for voice control in individuals with PD, which may be caused by their deficits in the detection and correction of errors in voice auditory feedback. Hum Brain Mapp 37:4248-4261, 2016. © 2016 Wiley Periodicals, Inc.</div></front></TEI><affiliations><list><country><li>Canada</li><li>République populaire de Chine</li></country><region><li>Guangdong</li></region><settlement><li>Shenzhen</li></settlement></list><tree><noCountry><name sortKey="Guo, Zhiqiang" sort="Guo, Zhiqiang" uniqKey="Guo Z" first="Zhiqiang" last="Guo">Zhiqiang Guo</name><name sortKey="Wang, Emily Q" sort="Wang, Emily Q" uniqKey="Wang E" first="Emily Q" last="Wang">Emily Q. Wang</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="Huang, Xiyan" sort="Huang, Xiyan" uniqKey="Huang X" first="Xiyan" last="Huang">Xiyan Huang</name></noRegion><name sortKey="Chen, Ling" sort="Chen, Ling" uniqKey="Chen L" first="Ling" last="Chen">Ling Chen</name><name sortKey="Chen, Xi" sort="Chen, Xi" uniqKey="Chen X" first="Xi" last="Chen">Xi Chen</name><name sortKey="Li, Weifeng" sort="Li, Weifeng" uniqKey="Li W" first="Weifeng" last="Li">Weifeng Li</name><name sortKey="Liu, Hanjun" sort="Liu, Hanjun" uniqKey="Liu H" first="Hanjun" last="Liu">Hanjun Liu</name><name sortKey="Liu, Peng" sort="Liu, Peng" uniqKey="Liu P" first="Peng" last="Liu">Peng Liu</name><name sortKey="Yan, Nan" sort="Yan, Nan" uniqKey="Yan N" first="Nan" last="Yan">Nan Yan</name></country><country name="Canada"><noRegion><name sortKey="Jones, Jeffery A" sort="Jones, Jeffery A" uniqKey="Jones J" first="Jeffery A" last="Jones">Jeffery A. 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